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8 FDA label tables · Checked

Indigestion vs placebo, out of 100 people

Zepbound label

Placebo4%
On Zepbound (by dose)9% to 10%

In the Zepbound label, 9% to 10% on Zepbound (by dose) had indigestion (dyspepsia). On placebo, 4% did.

See all 8 tables

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Indigestion on Zepbound vs placebo

ZepboundFDA-approved product

Zepbound trials in adults with obesity or overweight

Row name in our table: Indigestion (dyspepsia)

Placebo4%
On Zepbound (by dose)9% to 10%
Who was studied
Adults with obesity or overweight in 2 trials. One trial included only people with type 2 diabetes; the other left them out. 2,519 got Zepbound in three dose groups and 958 got placebo.
How long
Up to 72 weeks
Source
Zepbound prescribing information on DailyMed . FDA label revised August 2026.

How long were people on Zepbound watched?

Each bar is one set of trials and shows about how long people were in it.

Stated length Range in the source Some people only No end date given

  1. Egrifta, adults with HIV26 weeks

  2. Forteo, adults with osteoporosis11 months (men), 19 months (women)

  3. Mounjaro, adults with type 2 diabetes40 weeks

  4. Saxenda, adults32 to 56 weeks, some up to about 3 years

  5. Saxenda, teens56 weeks

  6. Victoza, adults with type 2 diabetesAt least 26 weeks each

  7. Wegovy, adultsUp to 68 weeks

  8. Zepbound, adultsUp to 72 weeksYour pick

See every table that lists indigestion

Every table that lists indigestion

Each dot is 1 in 100 people.

Reported it Rest of a dose range Did not report it

Filled dots show the low end of a range. Dots are rounded. The exact number is above each grid.

Placebo means a shot with no medicine in it. A number in a table is the share of people in a study who reported a problem. It is not your own chance of having it.

FDA-approved medicines

EgriftaFDA-approved product

Egrifta: Adults with HIV and extra belly fat, less common

Row name in our table: Indigestion

Placebo1%
On Egrifta2%
Who was studied
Adults with HIV and lipodystrophy in placebo-controlled trials. 543 got Egrifta and 263 got placebo.
How long
26 weeks
Source
Egrifta WR prescribing information on DailyMed . FDA label revised March 2025.

ForteoFDA-approved product

Forteo: Women and men with osteoporosis

Row name in our table: Upset stomach (dyspepsia)

Placebo4.1%
On Forteo5.2%
Who was studied
1,382 adults aged 28 to 86. 691 got Forteo and 691 got placebo. Everyone also took calcium and vitamin D. The middle trial length was 11 months for men and 19 months for women.
How long
11 months (men), 19 months (women)
Source
Forteo prescribing information on DailyMed . FDA label revised August 2026.

MounjaroFDA-approved product

Mounjaro trials in adults with type 2 diabetes

Row name in our table: Indigestion (dyspepsia)

Placebo3%
On Mounjaro (by dose)5% to 8%
Who was studied
Adults with type 2 diabetes in 2 trials. One tested Mounjaro alone. The other added it to long-acting insulin, with or without metformin. 718 adults took Mounjaro in three dose groups and 235 took placebo.
How long
40 weeks
Source
Mounjaro prescribing information on DailyMed . FDA label revised August 2026.

SaxendaFDA-approved product

Saxenda trials in adults with obesity or overweight

Row name in our table: Indigestion (dyspepsia)

Placebo2.7%
On Saxenda9.6%
Who was studied
Adults with obesity or overweight in 5 trials. 3,384 got Saxenda and 1,941 got placebo. 15% had type 2 diabetes. Everyone also got advice on diet and exercise.
How long
32 to 56 weeks, some up to about 3 years
Source
Saxenda prescribing information on DailyMed . FDA label revised February 2026.

SaxendaFDA-approved product

Saxenda trial in teens with obesity

Row name in our table: Indigestion (dyspepsia)

Placebo2.4%
On Saxenda4.0%
Who was studied
Children aged 12 and older with obesity. None had type 2 diabetes. 125 got Saxenda and 126 got placebo.
How long
56 weeks
Source
Saxenda prescribing information on DailyMed . FDA label revised February 2026.

VictozaFDA-approved product

Victoza trials in adults with type 2 diabetes

Row name in our table: Indigestion (dyspepsia)

Placebo1%
On Victoza (by dose)4% to 7%
Who was studied
Adults with type 2 diabetes in 5 trials. The table counts 1,669 adults on Victoza in two dose groups and 661 on placebo.
How long
At least 26 weeks each
Source
Victoza prescribing information on DailyMed . FDA label revised October 2025.

WegovyFDA-approved product

Wegovy trials in adults with obesity or overweight

Row name in our table: Indigestion (dyspepsia)

Placebo3%
On Wegovy9%
Who was studied
Adults with obesity or overweight in 3 trials. 2,116 got Wegovy and 1,261 got placebo. 19% had type 2 diabetes.
How long
Up to 68 weeks
Source
Wegovy prescribing information on DailyMed . FDA label revised June 2026.

ZepboundFDA-approved product

Zepbound trials in adults with obesity or overweight

Row name in our table: Indigestion (dyspepsia)

Placebo4%
On Zepbound (by dose)9% to 10%
Who was studied
Adults with obesity or overweight in 2 trials. One trial included only people with type 2 diabetes; the other left them out. 2,519 got Zepbound in three dose groups and 958 got placebo.
How long
Up to 72 weeks
Source
Zepbound prescribing information on DailyMed . FDA label revised August 2026.

How long were people watched?

Each bar is one set of trials and shows about how long people were in it.

Stated length Range in the source Some people only No end date given

  1. Egrifta, adults with HIV26 weeks

  2. Forteo, adults with osteoporosis11 months (men), 19 months (women)

  3. Mounjaro, adults with type 2 diabetes40 weeks

  4. Saxenda, adults32 to 56 weeks, some up to about 3 years

  5. Saxenda, teens56 weeks

  6. Victoza, adults with type 2 diabetesAt least 26 weeks each

  7. Wegovy, adultsUp to 68 weeks

  8. Zepbound, adultsUp to 72 weeks

Trials can miss rare harms and harms that take years to appear.

Other side effects

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Where the numbers come from

Every number is copied from a table on our side effect pages. Those tables come from FDA labels on DailyMed, results posted on ClinicalTrials.gov, and company trial results. We did not add, total, or rank any number. Rows keep one fixed order: FDA-approved medicines first, then the rest, each in A to Z order.

We group rows by name. For example, “Tiredness (fatigue)” and “Tiredness or weakness (fatigue)” are both under tiredness. Each row keeps the name it has in our side effect table.

The tables on this site copy part of each label, such as the most common problems. A problem missing from one table may still have happened.

Report a side effect

You can report a suspected side effect to the FDA at 1-800-FDA-1088 or through FDA MedWatch . If a reaction feels serious, get medical care first.

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