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7 FDA label and trial tables · Checked

Tiredness (fatigue) vs placebo, out of 100 people

Zepbound label

Placebo3%
On Zepbound (by dose)5% to 7%

In the Zepbound label, 5% to 7% on Zepbound (by dose) had tiredness or weakness (fatigue). On placebo, 3% did.

See all 7 tables

Every table that lists tiredness (fatigue)

Each dot is 1 in 100 people.

Reported it Rest of a dose range Did not report it

Filled dots show the low end of a range. Dots are rounded. The exact number is above each grid.

FDA-approved medicines

SaxendaFDA-approved product

Saxenda trials in adults with obesity or overweight

Row in the source: Tiredness (fatigue)

Placebo4.6%
On Saxenda7.5%
Who was studied
Adults with obesity or overweight in 5 trials. 3,384 got Saxenda and 1,941 got placebo. 15% had type 2 diabetes. Everyone also got advice on diet and exercise.
How long
32 to 56 weeks, some up to about 3 years
Source
Saxenda prescribing information on DailyMed . FDA label revised February 2026.

SaxendaFDA-approved product

Saxenda trial in teens with obesity

Row in the source: Tiredness (fatigue)

Placebo3.2%
On Saxenda4.8%
Who was studied
Children aged 12 and older with obesity. None had type 2 diabetes. 125 got Saxenda and 126 got placebo.
How long
56 weeks
Source
Saxenda prescribing information on DailyMed . FDA label revised February 2026.

TymlosFDA-approved product

Women after menopause with osteoporosis

Row in the source: Tiredness (fatigue)

Placebo2%
On Tymlos3%
Who was studied
Women aged 49 to 86. The label counts 822 women on Tymlos and 820 on placebo.
How long
18 months
Source
Tymlos prescribing information on DailyMed . FDA label revised August 2026.

VyleesiFDA-approved product

Premenopausal women with HSDD

Row in the source: Tiredness (fatigue)

Placebo0.5%
On Vyleesi3.2%
Who was studied
1,247 women aged 19 to 56 in two matching trials. 627 got Vyleesi and 620 got placebo.
How long
24 weeks
Source
Vyleesi prescribing information on DailyMed . FDA label revised March 2024.

WegovyFDA-approved product

Wegovy trials in adults with obesity or overweight

Row in the source: Tiredness or weakness (fatigue)

Placebo5%
On Wegovy11%
Who was studied
Adults with obesity or overweight in 3 trials. 2,116 got Wegovy and 1,261 got placebo. 19% had type 2 diabetes.
How long
Up to 68 weeks
Source
Wegovy prescribing information on DailyMed . FDA label revised June 2026.

ZepboundFDA-approved product

Zepbound trials in adults with obesity or overweight

Row in the source: Tiredness or weakness (fatigue)

Placebo3%
On Zepbound (by dose)5% to 7%
Who was studied
Adults with obesity or overweight in 2 trials. One trial included only people with type 2 diabetes; the other left them out. 2,519 got Zepbound in three dose groups and 958 got placebo.
How long
Up to 72 weeks
Source
Zepbound prescribing information on DailyMed . FDA label revised August 2026.

Medicines that are not FDA-approved

CagrilintideNo FDA-approved product

Phase 2 weight trial (NCT03856047)

Row in the source: Tiredness (fatigue)

Placebo3.0%
On cagrilintide (by dose)5.0% to 19.8%
Who was studied
706 adults without diabetes who had obesity, or overweight with high blood pressure or unhealthy blood-fat levels. 506 got cagrilintide and 101 got placebo. A liraglutide group of 99 is not shown.
How long
26 weeks of treatment, side effects counted to week 32
Source
ClinicalTrials.gov posted results . Trial registry results posted July 18, 2023.

How long were people watched?

Each bar is one set of trials. The dots on this page come only from the time inside each bar.

Stated length Range in the source Some people only

  1. Saxenda, adults32 to 56 weeks, some up to about 3 years

  2. Saxenda, teens56 weeks

  3. Tymlos, women18 months

  4. Vyleesi, women24 weeks

  5. Wegovy, adultsUp to 68 weeks

  6. Zepbound, adultsUp to 72 weeks

  7. Cagrilintide, phase 226 weeks of treatment, side effects counted to week 32

Trials can miss rare harms and harms that take years to appear.

Other side effects

Pick a medicine and side effect

Where the numbers come from

Every number is copied from a table on our side effect pages. Those tables come from FDA labels on DailyMed, results posted on ClinicalTrials.gov, and company trial results. We did not add, total, or rank any number. Rows keep one fixed order: FDA-approved medicines first, then the rest, each in A to Z order.

We group rows by name. For example, “Tiredness (fatigue)” and “Tiredness or weakness (fatigue)” are both under tiredness. Each row still shows its own words from the source.

The tables on this site copy part of each label, such as the most common problems. A problem missing from one table may still have happened.

Report a side effect

You can report a suspected side effect to the FDA at 1-800-FDA-1088 or through FDA MedWatch . If a reaction feels serious, get medical care first.

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