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6 FDA label and trial tables · Checked

Tingling or unusual skin feeling vs placebo, out of 100 people

Wegovy label

Placebo1%
On Wegovy2%

In the Wegovy label, 2% on Wegovy had changed skin feeling, like tingling or burning. On placebo, 1% did.

See all 6 tablesFrom the label: more on tingling or unusual skin feeling

Every table that lists tingling or unusual skin feeling

Each dot is 1 in 100 people.

Reported it Rest of a dose range Did not report it

Filled dots show the low end of a range. Dots are rounded. The exact number is above each grid.

FDA-approved medicines

EgriftaFDA-approved product

Adults with HIV and extra belly fat

Row in the source: Tingling or prickly skin (paresthesia)

Placebo2%
On Egrifta5%
Who was studied
Adults with HIV and lipodystrophy in placebo-controlled trials. 543 got Egrifta and 263 got placebo.
How long
26 weeks
Source
Egrifta WR prescribing information on DailyMed . FDA label revised March 2025.

VyleesiFDA-approved product

Premenopausal women with HSDD

Row in the source: Tingling or prickly skin (paresthesia)

Placebo0.0%
On Vyleesi2.6%
Who was studied
1,247 women aged 19 to 56 in two matching trials. 627 got Vyleesi and 620 got placebo.
How long
24 weeks
Source
Vyleesi prescribing information on DailyMed . FDA label revised March 2024.

WegovyFDA-approved product

Wegovy trials in adults, less common problems

Row in the source: Changed skin feeling, like tingling or burning

Placebo1%
On Wegovy2%
Who was studied
Adults with obesity or overweight in 3 trials. 2,116 got Wegovy and 1,261 got placebo. 19% had type 2 diabetes.
How long
Up to 68 weeks
Source
Wegovy prescribing information on DailyMed . FDA label revised June 2026.

Medicines that are not FDA-approved

RetatrutideNo FDA-approved product

TRIUMPH-1

Row in the source: Dysesthesia (unusual skin feeling)

Placebo0.9%
On retatrutide (by dose)5.1% to 12.5%
Who was studied
Adults without diabetes who had obesity, or overweight and at least one health problem linked to weight.
How long
80 weeks
Source
Lilly early results . Company trial results posted May 21, 2026. Company trial results were not yet checked by outside experts when we read them.

RetatrutideNo FDA-approved product

TRIUMPH-2

Row in the source: Dysesthesia (unusual skin feeling)

Placebo0.7%
On retatrutide (by dose)4.5% to 7.3%
Who was studied
Adults with type 2 diabetes and obesity or overweight.
How long
80 weeks
Source
Lilly early results . Company trial results posted July 23, 2026. Company trial results were not yet checked by outside experts when we read them.

RetatrutideNo FDA-approved product

TRIUMPH-3

Row in the source: Dysesthesia (unusual skin feeling)

Placebo1.3%
On retatrutide6.4%
Who was studied
Adults with severe obesity and heart or blood vessel disease, with or without type 2 diabetes.
How long
80 weeks
Source
Lilly early results . Company trial results posted July 23, 2026. Company trial results were not yet checked by outside experts when we read them.

More from the labels

These lines are copied from our side effect pages, word for word.

Higher-dose Wegovy (Wegovy HD)

Wegovy HD is a higher weekly dose. Two 72-week trials compared it with the usual Wegovy dose and with placebo. Nausea was reported by 39% on Wegovy HD, 35% on the usual dose, and 13% on placebo.

Changes in skin feeling, such as tingling, burning, or sensitive skin, were reported by 22%, 6%, and under 1%. Among people on Wegovy HD who had these skin changes, 18% did not report recovering during the trial. Hair loss was reported by 6%, 3%, and 1%.

From Wegovy prescribing information on DailyMed .

How long were people watched?

Each bar is one set of trials. The dots on this page come only from the time inside each bar.

  1. Egrifta, adults with HIV26 weeks

  2. Vyleesi, women24 weeks

  3. Wegovy, adultsUp to 68 weeks

  4. Retatrutide, TRIUMPH-180 weeks

  5. Retatrutide, TRIUMPH-280 weeks

  6. Retatrutide, TRIUMPH-380 weeks

Trials can miss rare harms and harms that take years to appear.

Other side effects

Pick a medicine and side effect

Where the numbers come from

Every number is copied from a table on our side effect pages. Those tables come from FDA labels on DailyMed, results posted on ClinicalTrials.gov, and company trial results. We did not add, total, or rank any number. Rows keep one fixed order: FDA-approved medicines first, then the rest, each in A to Z order.

We group rows by name. For example, “Tiredness (fatigue)” and “Tiredness or weakness (fatigue)” are both under tiredness. Each row still shows its own words from the source.

The tables on this site copy part of each label, such as the most common problems. A problem missing from one table may still have happened.

Report a side effect

You can report a suspected side effect to the FDA at 1-800-FDA-1088 or through FDA MedWatch . If a reaction feels serious, get medical care first.

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