3 trial tables · Checked

Stopped because of side effects vs placebo, out of 100 people

TRIUMPH-1

Placebo4.9%
On retatrutide (by dose)4.1% to 11.3%

In TRIUMPH-1, 4.1% to 11.3% on retatrutide (by dose) had stopped treatment because of side effects. On placebo, 4.9% did.

Every table that lists stopped because of side effects

Each dot is 1 in 100 people.

Reported it Rest of a dose range Did not report it

Filled dots show the low end of a range. Dots are rounded. The exact number is above each grid.

Medicines that are not FDA-approved

RetatrutideNo FDA-approved product

TRIUMPH-1

Row in the source: Stopped treatment because of side effects

Placebo4.9%
On retatrutide (by dose)4.1% to 11.3%
Who was studied
Adults without diabetes who had obesity, or overweight and at least one health problem linked to weight.
How long
80 weeks
Source
Lilly early results . Company trial results posted May 21, 2026. Company trial results were not yet checked by outside experts when we read them.

RetatrutideNo FDA-approved product

TRIUMPH-2

Row in the source: Stopped treatment because of side effects

Placebo4.9%
On retatrutide (by dose)3.8% to 11.6%
Who was studied
Adults with type 2 diabetes and obesity or overweight.
How long
80 weeks
Source
Lilly early results . Company trial results posted July 23, 2026. Company trial results were not yet checked by outside experts when we read them.

RetatrutideNo FDA-approved product

TRIUMPH-3

Row in the source: Stopped treatment because of side effects

Placebo4.8%
On retatrutide (by dose)9.8% to 13.5%
Who was studied
Adults with severe obesity and heart or blood vessel disease, with or without type 2 diabetes.
How long
80 weeks
Source
Lilly early results . Company trial results posted July 23, 2026. Company trial results were not yet checked by outside experts when we read them.

More from the labels

These lines are copied from our side effect pages, word for word.

Saxenda and Victoza: Stomach and bowel problems

6.2% of adults on Saxenda stopped because of these problems, compared with 0.8% on placebo. In the Victoza trials, 4.3% stopped for these reasons, compared with 0.5% on placebo. Most of these Victoza stops came in the first 2 to 3 months.

From Saxenda prescribing information on DailyMed  and Victoza prescribing information on DailyMed .

Wegovy: Stomach and bowel problems

4.3% of adults stopped Wegovy because of these problems, compared with 0.7% on placebo.

From Wegovy prescribing information on DailyMed .

Mounjaro and Zepbound: Stomach and bowel problems

In the Zepbound weight trials, 56% of adults on Zepbound and 30% on placebo had a stomach or bowel problem. 1.9% to 4.3% stopped Zepbound because of these problems, compared with 0.5% on placebo.

In the Mounjaro diabetes trials, 37.1% to 43.6% of adults on Mounjaro had a stomach or bowel problem, compared with 20.4% on placebo. 3.0% to 6.6% stopped Mounjaro because of them, compared with 0.4% on placebo.

From Mounjaro prescribing information on DailyMed  and Zepbound prescribing information on DailyMed .

How long were people watched?

Each bar is one set of trials. The dots on this page come only from the time inside each bar.

  1. Retatrutide, TRIUMPH-180 weeks

  2. Retatrutide, TRIUMPH-280 weeks

  3. Retatrutide, TRIUMPH-380 weeks

Trials can miss rare harms and harms that take years to appear.

Other side effects

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Where the numbers come from

Every number is copied from a table on our side effect pages. Those tables come from FDA labels on DailyMed, results posted on ClinicalTrials.gov, and company trial results. We did not add, total, or rank any number. Rows keep one fixed order: FDA-approved medicines first, then the rest, each in A to Z order.

We group rows by name. For example, “Tiredness (fatigue)” and “Tiredness or weakness (fatigue)” are both under tiredness. Each row still shows its own words from the source.

The tables on this site copy part of each label, such as the most common problems. A problem missing from one table may still have happened.

Report a side effect

You can report a suspected side effect to the FDA at 1-800-FDA-1088 or through FDA MedWatch . If a reaction feels serious, get medical care first.

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