Review · United States
Sermorelin
Reviewed on
Approval and product status
This review found no current FDA-approved sermorelin product in the United States. Former Geref products were FDA-approved and are no longer sold. FDA said safety or effectiveness was not the reason for their withdrawal.
A former Geref approval does not make a current product FDA-approved. Current compounded sermorelin products are not automatically the same as the former Geref products.
What was measured in people?
- Health results · Limited
- Older studies in children exist. Research does not show that current products slow aging, reduce body fat, or build muscle.
- Body changes · Moderate
- Studies in people show that sermorelin can trigger growth-hormone release. A body response alone does not prove a health benefit.
A change in a hormone or body signal does not by itself prove a health benefit.
Important limits
This tool is not an independent medical review. It does not recommend treatment.
Approval of a former product does not prove the quality of a current product. This guide gives no dose, injection, or compounding instructions.
Still unknown: Reliable studies do not show that current compounded sermorelin products slow aging or build muscle. They also do not show less body fat, better sleep, or that people live longer.
This record cannot check a package, seller, batch, or personal treatment. It does not provide sport clearance.
Approval fact checks
“Sermorelin was once FDA-approved.”
Supported with scope. FDA records document the former Geref approvals. FDA later found that safety or effectiveness was not the reason for withdrawal.
Applies to: Historical Geref products, not current compounded sermorelin.
Products in this review
These are selected records, not every product or form.
No product label record is included here. That is not a separate approval decision. Read the status and sources above.
What the research shows
Studies in people show that sermorelin can trigger growth-hormone release. Older studies in children found limited growth results. A hormone response is not the same as a health benefit. These studies do not prove benefits for current compounded products.
Read all Sermorelin fact checksSources used in this review
A source may support some statements, not all of them. Use the links above or this review to see what each source supports.
Show 5 sources
- Geref (sermorelin acetate) approval package
U.S. Food and Drug Administration · FDA review · 1991
Source accessed
- FDA determination that Geref was not withdrawn for safety or effectiveness
Federal Register · U.S. Food and Drug Administration · Regulatory · 2013
Source accessed
- Current Drugs@FDA records for sermorelin
openFDA · U.S. Food and Drug Administration · Regulatory · 2026
Source accessed
- Sermorelin in diagnosis and treatment of pediatric growth hormone deficiency
PubMed · BioDrugs · Science review · 1999
Source accessed
- 2026 Prohibited List
World Anti-Doping Agency · Anti-doping · 2026
Source accessed