{ "schemaVersion": "2.1", "datasetVersion": "2026-09-11.1", "generatedAt": "2026-09-11", "reviewStatus": "Editorial source review is complete. This edition has not been independently medically reviewed.", "editorialBoundary": "Source-checked educational summaries. Topics require evidence and editorial review. This dataset is not a personal treatment plan.", "citation": "When you cite a record, include The Peptide Field, its canonicalPath, this dataset version, and every source used for the claim.", "reuse": "This endpoint grants no additional reuse license. Keep the verdict, scope, evidence basis, review date, and source links together. Do not present a record as medical advice or medical review.", "changeLogPath": "/corrections#correction-ledger", "contactPath": "/corrections", "dataset": "peptide-evidence-checker-record", "canonicalPath": "/peptides/sermorelin", "canonicalUrl": "https://thepeptidefield.com/peptides/sermorelin", "record": { "slug": "sermorelin", "name": "Sermorelin", "aliases": [ "Geref", "GRF 1-29", "GHRH(1-29)" ], "className": "Growth hormone-releasing hormone analogue", "family": "Growth signaling", "sequenceLabel": "29 amino acids · GHRH fragment", "tier": "Emerging", "evidenceContext": "Human pharmacology only", "statusLine": "This review found no current FDA-approved sermorelin product in the United States. Former Geref products were FDA-approved and are no longer sold. FDA said safety or effectiveness was not the reason for their withdrawal.", "productContext": "A former Geref approval does not make a current product FDA-approved. Current compounded sermorelin products are not automatically the same as the former Geref products.", "approvedProducts": [], "indications": [ "Historical diagnostic and pediatric growth-hormone-deficiency uses" ], "profile": { "humanOutcomes": { "level": "Limited", "note": "Older studies in children exist. Research does not show that current products slow aging, reduce body fat, or build muscle." }, "humanPharmacology": { "level": "Moderate", "note": "Studies in people show that sermorelin can trigger growth-hormone release. A body response alone does not prove a health benefit." }, "safetyKnowledge": { "level": "Limited", "note": "Past records do not fully show whether modern compounded products are safe. They also do not show the safety of long-term use for wellness." }, "productCertainty": { "level": "Limited", "note": "FDA records clearly describe the former Geref products. The identity and quality of each current compounded product must be checked separately." } }, "oneLine": "Studies in people show a growth-hormone response. They do not prove broad anti-aging or muscle-building benefits. Former Geref products are no longer sold.", "reviewedAt": "July 23, 2026", "reviewedAtISO": "2026-07-23", "reviewHistory": [ { "date": "2026-07-23", "note": "Updated with FDA's 2013 determination that the discontinued Geref products were not withdrawn for safety or effectiveness." } ], "whatItIs": "Sermorelin is a 29-amino-acid piece of growth hormone-releasing hormone (GHRH). GHRH is a body signal that helps the body release growth hormone. Geref products containing sermorelin were once FDA-approved and later discontinued. In 2013, FDA said the products were not withdrawn for safety or effectiveness.", "whatWeKnow": "Studies in people show that sermorelin can trigger growth-hormone release. Older studies in children found limited growth results. A hormone response is not the same as a health benefit. These studies do not prove benefits for current compounded products.", "whatWeDoNotKnow": "Reliable studies do not show that current compounded sermorelin products slow aging or build muscle. They also do not show less body fat, better sleep, or that people live longer.", "antiDoping": "The 2026 World Anti-Doping Agency (WADA) list names sermorelin as prohibited.", "antiDopingReview": { "status": "Prohibited", "detail": "The 2026 WADA list names sermorelin as a prohibited growth hormone-releasing hormone analogue.", "sourceUrl": "https://www.wada-ama.org/en/resources/world-anti-doping-program/prohibited-list", "reviewedAtISO": "2026-07-23" }, "safetyBoundary": "Approval of a former product does not prove the quality of a current product. This guide gives no dose, injection, or compounding instructions.", "relatedSlugs": [ "tesamorelin", "cjc-1295", "ipamorelin" ], "claims": [ { "claim": "“Sermorelin was once FDA-approved.”", "verdict": "Supported with scope", "explanation": "FDA records document the former Geref approvals. FDA later found that safety or effectiveness was not the reason for withdrawal.", "category": "Approval and status", "evidenceBasis": "Regulatory or product record", "scope": "Historical Geref products, not current compounded sermorelin.", "sourceUrls": [ "https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/019863_S001_GEREF.pdf", "https://www.govinfo.gov/content/pkg/FR-2013-03-04/pdf/2013-04827.pdf" ] }, { "claim": "“Sermorelin raises growth hormone, so it is proven to slow aging.”", "verdict": "Misleading", "explanation": "A hormone response cannot show that people live longer or age more slowly.", "category": "Longevity", "evidenceBasis": "Human pharmacology", "scope": "Hormone-response evidence cannot establish longer life or slower biological aging.", "sourceUrls": [ "https://pubmed.ncbi.nlm.nih.gov/18031173/" ] }, { "claim": "“Compounded sermorelin is an FDA-approved Geref generic.”", "verdict": "Misleading", "explanation": "A former Geref approval does not make current compounded products FDA-approved. Current compounded products are not automatically the same as the former Geref products.", "category": "Product equivalence", "evidenceBasis": "Regulatory or product record", "scope": "Current products marketed after Geref withdrawal.", "sourceUrls": [ "https://www.govinfo.gov/content/pkg/FR-2013-03-04/pdf/2013-04827.pdf" ] } ], "sources": [ { "label": "Geref (sermorelin acetate) approval package", "publisher": "U.S. Food and Drug Administration", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/pre96/019863_S001_GEREF.pdf", "kind": "FDA review", "year": 1991, "accessedAt": "2026-07-23" }, { "label": "FDA determination that Geref was not withdrawn for safety or effectiveness", "publisher": "Federal Register · U.S. Food and Drug Administration", "url": "https://www.govinfo.gov/content/pkg/FR-2013-03-04/pdf/2013-04827.pdf", "kind": "Regulatory", "year": 2013, "accessedAt": "2026-07-23" }, { "label": "Current Drugs@FDA records for sermorelin", "publisher": "openFDA · U.S. Food and Drug Administration", "url": "https://api.fda.gov/drug/drugsfda.json?search=products.active_ingredients.name:%22SERMORELIN%22&limit=10", "kind": "Regulatory", "year": 2026, "accessedAt": "2026-07-23" }, { "label": "Sermorelin in diagnosis and treatment of pediatric growth hormone deficiency", "publisher": "PubMed · BioDrugs", "url": "https://pubmed.ncbi.nlm.nih.gov/18031173/", "kind": "Science review", "year": 1999, "accessedAt": "2026-07-23" }, { "label": "2026 Prohibited List", "publisher": "World Anti-Doping Agency", "url": "https://www.wada-ama.org/en/resources/world-anti-doping-program/prohibited-list", "kind": "Anti-doping", "year": 2026, "accessedAt": "2026-07-23" } ], "productRecords": [] } }